NamePurpose / DescriptionFile formatsPlatformFree or Paid?Link to toolNotes
AliViewGenomics data viewer
AmnesiaFinds direct and indirect identifiers
ArcGISOpening and checking spatial data filesWindowsPaid
ArtemisGenomic sequence visualizationBrowserFreehttps://www.sanger.ac.uk/science/tools/artemis
AstroPiFITS files (astrofiles)
AutoDesk ViewerCADIn-browser (Firefox, Chrome tested)Freehttps://viewer.autodesk.com/Account necessary for use.
BamViewGenomic sequence visualization for .BAM filesMacOSX, Windows and UnixFreehttp://bamview.sourceforge.net/
BulkExtractorOutput is a file tree
Bruker TopSpinAllows viewing and processing of NMR data files (Bruker)https://www.bruker.com/service/support-upgrades/software-downloads/nmr.htmlFree for academic users (with .edu email address)
ChemDraw.MOL files (chemical structures – lossy)
Code OceanAllows you to reproduce coding environment to verify Paid
Excel Archival ToolProgrammatically convert Excel files into open-source formats and extracts charts/figures, etc.WindowsFreehttps://github.com/mcgrory/ExcelArchivalToolU of M grad student built. Any issues, contact him!
FiguresObscure figure/graph raw files (igor)
FijiScientific image processing (aka giant files)Windows, MacOS, LinuxFreehttps://fiji.sc/Fiji is an image processing package—a “batteries-included” distribution of ImageJ.
Free File SplitterBreaks large files into more maneagable “chunks” to work with, can rejoin files after evaluation or changes are made Freehttps://www.filesplitter.org/Only works for brute force splitting – will break off in the middle of a line of text or code
GeoNetwork
GLOGGOpens massive text fileshttp://glogg.bonnefon.org/index.html
HashMyFilesMaps files, shows hashes
Identity FinderTries to detect well-formatted sensitive informationWindows / Server level
IDLAstronomical/Atmospheric files (space .py package)
ImageJScientific image processing (aka giant files)Windows, MacOS, LinuxFreehttps://imagej.nih.gov/ij/ImageJ is a public domain Java image processing program.
iNMRAllows you to view and process NMR data filesFree limited use (each work session is limited to 30 minutes)
Jena3D molecular structure/Crystallographic fileshttp://jenalib.leibniz-fli.de/
JHOVEFile verification
MangoCT/MRI image files
MatlabComputation and visualizationWindows, MacOS, LinuxPaidhttps://www.mathworks.com/
MediaInfoMediaInfo is a convenient unified display of the most relevant technical and tag data for video and audio files.Audiovisual filesFreehttps://mediaarea.net/en/MediaInfo
MesquitePlant genetics/evolutionary biologyWindows, MacOS, LinuxFreehttps://www.mesquiteproject.org/
MicroViewMicroView is a 2D/3D image viewer and analysis tool. It is written in Python and uses VTK for all of its graphical capabilities.Freehttps://sourceforge.net/projects/microview/
MRICROCT/MRI image files
MZmineMass spec data files
NARA File AnalyzerForensic tool – detects if file is what it says it is
NCAR command languageClimate science (netCDF)
NCViewClimate science (netCDF)
NotePad++Opens most files if another tool won’t, does other diagnostic things
Octavehttps://www.gnu.org/software/octave/
OmeroMicroscopic images
OsiriXCT/MRI image files
PanoplyJava application for climate science (netCDF)Windows, MacOS, LinuxFreehttps://www.giss.nasa.gov/tools/panoply/
Print WindowMaps files
QGISOpening and checking spatial data filesFreehttps://qgis.org/
Repro ZipAllows you to reproduce coding environment data was analyzed in (like docker) 
RStudio
SciLabOpen source alternative to MatlabWindows, MacOs, LinuxFreehttps://www.scilab.org/
TADOpens CSV files (and keeps table structure)
TreeMaps file directoriesFreehttps://www.digitalcitizen.life/how-export-directory-tree-folder-windowsCommand line in Windows: tree /a /f > output.txt
Command line in Mac (first install Tree with Homebrew): tree -hF > ~/Desktop/output.txt
https://rschu.me/list-a-directory-with-tree-command-on-mac-os-x-3b2d4c4a4827
WebAIM Contrast Checkerchecks image contrast and color accessibility, has bookmarklet! Web-basedfreehttps://webaim.org/resources/contrastchecker/